Eating disorders represent a significant public health concern, affecting individuals across different age groups and often co-occurring with other conditions such as obesity, anxiety, and depression. These disorders are not merely about food or weight; they are serious mental health conditions that can have profound impacts on physical and psychological well-being. Effective management requires a multifaceted approach, often combining psychological therapies, lifestyle adjustments, and sometimes medication, tailored to the individual's specific needs and circumstances [3].
The Link Between Eating Disorders and Obesity
Obesity is a complex chronic disease that frequently has psychological consequences, and there is a recognized bidirectional relationship between obesity and mental health conditions, including maladaptive eating behaviors [2]. Many individuals living with obesity also meet the diagnostic criteria for an eating disorder, such as Binge Eating Disorder (BED) or Bulimia Nervosa (BN) [6]. For example, BED is commonly observed in adults who also have type 2 diabetes, creating a dual challenge for both mental well-being and blood sugar management [4].
Research indicates that behavioral weight management interventions, which focus on lifestyle changes, can actually lead to a decrease in eating disorder symptoms for individuals diagnosed with BED or BN. Importantly, these interventions do not appear to worsen the symptoms of these disorders [6]. This suggests that addressing weight management in a supportive, behavioral context can be beneficial for individuals with co-occurring eating disorders and obesity.
Psychological Distress and Disordered Eating
Psychological distress is a common companion to disordered eating and obesity. Studies have shown that adults attending obesity outpatient clinics often experience moderate to very severe levels of psychological distress, including symptoms of depression and anxiety [2]. These mental health challenges can play a critical role in the development and maintenance of obesity, as well as influence how individuals respond to treatment [2].
For adolescents, anxiety, depressive, and eating disorders are a growing concern. Primary care clinicians play a vital role in identifying these issues, with universal screening for depression recommended at age 12 and for anxiety at age 8 [3]. A correct diagnosis relies on referencing the diagnostic criteria outlined in the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5), after ruling out any underlying medical conditions [3].
Treatment Approaches for Eating Disorders
Treatment for eating disorders is highly individualized and often involves a combination of strategies. For conditions like BED that co-occur with type 2 diabetes, interventions may include both pharmacological and psychological approaches. Glucagon-like peptide-1 receptor agonists (GLP-1RAs) are one type of medication that has been evaluated, alongside psychological therapies such as cognitive behavioral therapy (CBT) [4].
In the broader context of obesity management, anti-obesity medications (AOMs) like semaglutide, naltrexone/bupropion, and liraglutide are used. The effectiveness of these medications can be influenced by an individual's specific eating behavior phenotypes. Tools like the Brazilian Eating Behavior Phenotype Scale (EFCA) are being explored to help clinicians tailor AOM selection based on these behavioral patterns, moving towards more precision pharmacotherapy [1]. Other dietary approaches, such as the Mediterranean Diet and Ketogenic Diet, have also shown significant changes in body mass index (BMI) in adults with overweight and obesity [5].
Special Considerations for Adolescents
Adolescence is a critical period, and the management of obesity in this age group requires careful attention due to the increased risk of disordered eating. While lifestyle changes, including dietary modifications and increased physical activity, are foundational for improving health in adolescent females, the combination of provider-encouraged weight loss and societal stigma around obesity can heighten the risk for developing disordered eating [7]. Furthermore, there is a high prevalence of mental health issues among adolescents with obesity [7].
Pediatric obesity management often involves health behavior and lifestyle treatment (HBLT) as a primary approach. In some cases, pharmacotherapies, including GLP-1RAs, metformin, orlistat, and phentermine/topiramate, may be considered, sometimes in combination with HBLT, for children and adolescents aged 10-19 years [8].
Toward Personalized Care
The evolving understanding of eating disorders and their connections to other health conditions highlights the need for personalized and comprehensive care. Recognizing the psychological dimensions of obesity and the specific eating behavior phenotypes can help clinicians select more targeted and effective treatments [1, 2]. Integrating mental health screenings and support into primary care and specialized clinics is crucial for early diagnosis and intervention, ultimately improving outcomes for individuals struggling with these complex conditions [3].
Sources
- [1] Toward Precision Obesity Pharmacotherapy: Using the Eating Behavior Phenotype Scale (EFCA) in Real-World Clinical Practice. (Nutrients, 2026) https://pubmed.ncbi.nlm.nih.gov/42124020/
- [2] Psychological Distress and Disordered Eating in Adults Attending an Obesity Outpatient Clinic. (Diabetes, metabolic syndrome and obesity : targets and therapy, 2026) https://pubmed.ncbi.nlm.nih.gov/42293293/
- [3] Anxiety, Depressive, and Eating Disorders in Adolescents. (Primary care, 2024) https://pubmed.ncbi.nlm.nih.gov/39448100/
- [4] Interventions for binge eating disorder in adults with type 2 diabetes: A systematic review. (Diabetic medicine : a journal of the British Diabetic Association, 2026) https://pubmed.ncbi.nlm.nih.gov/42036870/
- [5] Current perspectives in obesity management: unraveling the impact of different therapy approach in real life obesity care. (Journal of translational medicine, 2024) https://pubmed.ncbi.nlm.nih.gov/38844956/
- [6] Effect of Behavioral Weight Management Interventions on Symptoms of Binge-Eating Disorder and Bulimia Nervosa: A Systematic Review and Meta-Analysis. (Obesity reviews : an official journal of the International Association for the Study of Obesity, 2026) https://pubmed.ncbi.nlm.nih.gov/42167881/
- [7] Obesity Management in Female Adolescents. (Clinical endocrinology, 2025) https://pubmed.ncbi.nlm.nih.gov/40255106/
- [8] Obesity Management Pharmacotherapies and Lifestyle Treatment for Pediatric Obesity Management: A Systematic Review and Network Meta-Analysis. (JAMA pediatrics, 2026) https://pubmed.ncbi.nlm.nih.gov/42329656/